This chapter looks at case studies around initiatives that have facilitated the participation of smallholder farmers in food value chains, especially the role of multi-stakeholder and public-private partnerships to foster participation, having as a target group smallholder farmers. A multi-stakeholder sustainability partnership is an organization formed by a number of actors, particularly multinational companies who engage with actors along the value chain, to deal with complex problems that are called global or grand challenges. These create inter-sectoral dialogue and may achieve transformation or reconfiguration of the value chain. It is necessary to create a number of shared values to facilitate participation in the value chain. It can be difficult and costly to measure the performance of participation in the chain. There is an experimental and design phase, when pilot plans may be developed and tested. In the experimental approach, a two-level perspective is designed. This chapter is part of Module 7: How to Achieve the Sustainable Development Goals (SDG) in the Mediterranean – The Way Forward III. Food Value Chain for Regional and Local Development.