Novel entities refer to the release of chemical pollution into the environment, which signals a focus on the role of human-caused changes that fundamentally change biogeochemical, ecological, and physical processes at the global level. These changes bypass the self-correcting processes of the planet. The new synthetic substance (novel entities), persistent organic pollutants, and the production of highly reactive radioactive heavy metals that can be transported through water and atmosphere are concerning. Examples are given of these novel entities that become globally-distributed problems. There is a very high risk of irreversiblility, as well as an obstacle due to the sheer number of substances that can be considered novel entities, so we must apply the precautionary principle.